Diclofenac diethylamine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

双氯芬酸二乙胺是一种非选择性 COX 抑制剂，用作非甾体抗炎药 (NSAID)。

Diclofenac Diethylamine is a non-selective COX inhibitor used as a nonsteroidal anti-inflammatory drug (NSAID).(In Vitro):Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7±3 nM.Diclofenac (1-60 μM; 1 day) induces neural stem cells (NSCs)death in a concentration-dependent manner.Diclofenac (10-60 μM; 6 hours) increases the expression of cleaved (activated) caspase-3.(In Vivo):Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days.Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats.

Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7±3 nM. Diclofenac (1-60 μM; 1 day) induces neural stem cells (NSCs)death in a concentration-dependent manner.Diclofenac (10-60 μM; 6 hours) increases the expression of cleaved (activated) caspase-3. Cell Viability Assay Cell Line:Neural stem cells (NSCs)Concentration:1, 3, 10, 30, 60 μM Incubation Time:1 day Result:Induction of cell death was concentration-dependent and the effect was not saturated at a concentration of up to 60 μM.Western Blot Analysis Cell Line:Neural stem cells (NSCs) Concentration:10, 30 or 60 μM Incubation Time:6 hours Result:The activation of caspase-3 was increased in a concentration-dependent manner.

Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days. Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats. Animal Model:Male Sprague-Dawley rats (150±200 g) Dosage:3 mg/kg Administration:Oral administration, b.i.d., for 5 days Result:Resulted in a significant increase in faecal 51Cr excretion.Animal Model:Wistar rats (150-175 g) bearing Formalin-induced rat foot paw edema modelDosage:10 mg/kg Administration:Administered via oral route just prior to induction of inflammation Result:Showed in vivo anti-inflammatory activity (% edema inhibition=29.2, 1 h; 22.2, 3 h; 20, 6 h).

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Others

Other Targets

Others

Inflammation/Immunology

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78213-16-8

369.29

C18H22Cl2N2O2

>98% (HPLC)

Ethanol: 74 mg/mL (200.38 mM); DMSO: 74 mg/mL (200.38 mM)

CCNCC.OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl

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(-20℃)

With Ice Pack

≥ 2 years